The recent test invention of researchers is CRISPR gene-editing technology that ables to detect the pandemic Coronavirus in merely 5 minutes. Such kind of testing doesn’t put you in a position that you need to run on the costly lab tools to check up yourself on Covid-19.
Even more: such technology can let people run on tests in schools, offices in several minutes without going to the doctor’s office.
You can pay attention to the expression of the molecular biologist from the University of California (UC) – Max Wilson. He says: “It looks like they have a really rock-solid test. It’s really quite elegant.”
CRISPR diagnostics can be a key instrument to free the world from the pandemic of Covid-19. This technology may speed coronavirus testing and give a green light for those people that can’t afford other tests. For instance, there is positive information from a group of scientific teams in form of a report dated back to May 2020. It took only 60 minutes instead of ordinary 24 hours to do a coronavirus diagnostic test.
CRISPR tests act by recognizing a sequence of RNA — about 20 RNA bases long — that is unusual to SARS-CoV-2. They do so by formulating a “model” RNA that is equal to the target RNA sequence and will bind to it in a positive answer.
The second huge advantage is the ability to quantify a sample’s quantity of virus. CRISPR diagnostics changes the number of the genetic material present, while standard coronavirus tests increase the virus’ genetic material to match it.
The team led by Otto and Doudna discovered that the power of the fluorescent signal was equal to the amount of virus in their sample. The test has shown not only whether the sample is positive but spotted the amount of the virus in the patient’s organism. It can help doctors make appropriate decisions concerning each case of a patient.
The pilot CRISPR diagnostic tests were used to obligate scientists to increase any possible viral RNA before managing it into the diagnostic to boost their odds of spotting a signal. Because of it the price, time, and complexity were extra added to the list that influenced the lack of chemical reagents.
The time has passed and the followers of such technology trying to find a new way of solving such a situation. For example, a team on the head of which is Jennifer Doudna reports about creating a new kind of CRISPR diagnostic. It is unique and gets unto a spotlight because it doesn’t increase coronavirus RNA. Instead of it, researchers trying to create multiple guides that will be working in tandem to improve the sensitivity of the test.
The problem also lays in that scientists state that with single-guide RNA they might identify as few as 100,000 viruses per microliter of solution. If they join a second guide RNA to help the first one it can be distinguished only as few as 100 viruses per microliter.
The virologist at UC San Francisco, Melanie Ott, points that is still not as guaranteed as the standard coronavirus diagnostic composition, which works deluxe lab-based machines to trace the virus to one virus per microliter.
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